Biodegradable-co-bioresponsive Hydrogels for Controlled Release of Growth Factor
نویسندگان
چکیده
A series of multi-functional hydrogel systems have been designed and synthesized for potential brain implantation to realize controlled and sustained release of Nerve Growth Factor (NGF) for the treatment of Alzheimer’s disease (AD). The systems are three-dimensional crosslinked copolymers composed of a thermo-responsive unit, a hydrolytically degradable and hydrophobic unit, and an enzymatically degradable and hydrophilic unit. They combine the merits of thermo-responsive and biodegradable polymeric drug delivery systems, and allow a low-temperature aqueous NGF loading to prevent protein denaturation. The hydrogels show a lower critical solution temperature (LCST) at approximately 32 C, and demonstrate different swelling and release profiles at temperatures above (37 C) and below (25 C) the LCST.
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